Preformed CD40 ligand exists in secretory lysosomes in effector and memory CD4(+) T cells and is quickly expressed on the cell surface in an antigen-specific manner

CD40 ligand (CD40L) is an essential effector cytokine for macrophage activation, dendritic cell licensing, and T-cell–dependent antibody responses. Although CD40L is known to be made de novo following antigen recognition, several reports have described surface mobilization of preformed, intracellula...

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Bibliographische Detailangaben
Hauptverfasser: Koguchi, Yoshinobu, Thauland, Timothy J., Slifka, Mark K., Parker, David C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2007
Schlagworte:
Immunobiology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1988919/
https://ncbi.nlm.nih.gov/pubmed/17595332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-03-081299
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