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Preformed CD40 ligand exists in secretory lysosomes in effector and memory CD4(+) T cells and is quickly expressed on the cell surface in an antigen-specific manner
CD40 ligand (CD40L) is an essential effector cytokine for macrophage activation, dendritic cell licensing, and T-cell–dependent antibody responses. Although CD40L is known to be made de novo following antigen recognition, several reports have described surface mobilization of preformed, intracellula...
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| Asıl Yazarlar: | , , , |
|---|---|
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
American Society of Hematology
2007
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1988919/ https://ncbi.nlm.nih.gov/pubmed/17595332 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-03-081299 |
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