Responsiveness of HIV-specific CD4 T cells to PD-1 blockade

Defining the T helper functions impaired by programmed death–1 (PD-1) is crucial for understanding its role in defective HIV control and determining the therapeutic potential of targeting this inhibitory pathway. We describe here the relationships among disease stage, levels of PD-1 expression, and...

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Detalhes bibliográficos
Main Authors: Porichis, Filippos, Kwon, Douglas S., Zupkosky, Jennifer, Tighe, Daniel P., McMullen, Ashley, Brockman, Mark A., Pavlik, David F., Rodriguez-Garcia, Marta, Pereyra, Florencia, Freeman, Gordon J., Kavanagh, Daniel G., Kaufmann, Daniel E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2011
Assuntos:
Immunobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3148173/
https://ncbi.nlm.nih.gov/pubmed/21652684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-12-328070
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