IL-10 is up-regulated in multiple cell types during viremic HIV infection and reversibly inhibits virus-specific T cells

Murine models indicate that interleukin-10 (IL-10) can suppress viral clearance, and interventional blockade of IL-10 activity has been proposed to enhance immunity in chronic viral infections. Increased IL-10 levels have been observed during HIV infection and IL-10 blockade has been shown to enhanc...

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Detalhes bibliográficos
Main Authors: Brockman, Mark A., Kwon, Douglas S., Tighe, Daniel P., Pavlik, David F., Rosato, Pamela C., Sela, Jennifer, Porichis, Filippos, Le Gall, Sylvie, Waring, Michael T., Moss, Kristin, Jessen, Heiko, Pereyra, Florencia, Kavanagh, Daniel G., Walker, Bruce D., Kaufmann, Daniel E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2009
Assuntos:
Immunobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2714209/
https://ncbi.nlm.nih.gov/pubmed/19365081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-12-191296
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