CD4(+) CD25(+) Regulatory T Cells Impair HIV-1-Specific CD4 T Cell Responses by Upregulating Interleukin-10 Production in Monocytes

T cell dysfunction in the presence of ongoing antigen exposure is a cardinal feature of chronic viral infections with persistent high viremia, including HIV-1. Although interleukin-10 (IL-10) has been implicated as an important mediator of this T cell dysfunction, the regulation of IL-10 production...

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Detalhes bibliográficos
Main Authors: Kwon, Douglas S., Angin, Mathieu, Hongo, Tomoyuki, Law, Kenneth M., Johnson, Jessica, Porichis, Filippos, Hart, Meghan G., Pavlik, David F., Tighe, Daniel P., Kavanagh, Daniel G., Streeck, Hendrik, Addo, Marylyn M., Kaufmann, Daniel E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3393541/
https://ncbi.nlm.nih.gov/pubmed/22496237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.06251-11
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