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In Vitro Assay to Evaluate the Impact of Immunoregulatory Pathways on HIV-specific CD4 T Cell Effector Function
T cell exhaustion is a major factor in failed pathogen clearance during chronic viral infections. Immunoregulatory pathways, such as PD-1 and IL-10, are upregulated upon this ongoing antigen exposure and contribute to loss of proliferation, reduced cytolytic function, and impaired cytokine productio...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MyJove Corporation
2013
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3940612/ https://ncbi.nlm.nih.gov/pubmed/24193166 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3791/50821 |
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