Expansion of HIV-specific CD4(+) and CD8(+) T cells by dendritic cells transfected with mRNA encoding cytoplasm- or lysosome-targeted Nef

Transfection with synthetic mRNA is a safe and efficient method of delivering antigens to dendritic cells for immunotherapy. Targeting antigens to the lysosome can sometimes enhance the CD4(+) T-cell response. We transfected antigen-presenting cells (APCs) with mRNA encoding Gag-p24 and cytoplasmic,...

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Hlavní autoři: Kavanagh, Daniel G., Kaufmann, Daniel E., Sunderji, Sherzana, Frahm, Nicole, Le Gall, Sylvie, Boczkowski, David, Rosenberg, Eric S., Stone, David R., Johnston, Mary N., Wagner, Bradford S., Zaman, Mohammad T., Brander, Christian, Gilboa, Eli, Walker, Bruce D., Bhardwaj, Nina
Médium: Artigo
Jazyk:Inglês
Vydáno: © 2006 by The American Society of Hematology 2006
Témata:
Immunobiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895708/
https://ncbi.nlm.nih.gov/pubmed/16249391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-04-1513
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