Ablation of oncogenic ALK is a viable therapeutic approach for anaplastic large-cell lymphomas

Anaplastic large-cell lymphomas (ALCLs) carry chromosome translocations in which the anaplastic lymphoma kinase (ALK) gene is fused to several partners, most frequently, the NPM1 gene. We have demonstrated that the constitutive activation of ALK fusion proteins results in cellular transformation and...

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Detalhes bibliográficos
Main Authors: Piva, Roberto, Chiarle, Roberto, Manazza, Andrea D., Taulli, Riccardo, Simmons, William, Ambrogio, Chiara, D'Escamard, Valentina, Pellegrino, Elisa, Ponzetto, Carola, Palestro, Giorgio, Inghirami, Giorgio
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society of Hematology 2006
Assuntos:
Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895619/
https://ncbi.nlm.nih.gov/pubmed/16189272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-05-2125
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