Anti-CD20 monoclonal antibody with enhanced affinity for CD16 activates NK cells at lower concentrations and more effectively than rituximab

Growing evidence indicates that the affinity of monoclonal antibodies (mAbs) for CD16 (FcγRIII) plays a central role in the ability of the mAb to mediate antitumor activity. We evaluated how CD16 polymorphisms, and mAb with modified affinity for target antigen and CD16, affect natural killer (NK) ce...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Bowles, Julie A., Wang, Siao-Yi, Link, Brian K., Allan, Barrett, Beuerlein, Gregory, Campbell, Mary-Ann, Marquis, David, Ondek, Brian, Wooldridge, James E., Smith, Brian J., Breitmeyer, James B., Weiner, George J.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: © 2006 by The American Society of Hematology 2006
विषय:
Immunobiology
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895597/
https://ncbi.nlm.nih.gov/pubmed/16825493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-04-020057
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