NK-cell activation and antibody-dependent cellular cytotoxicity induced by rituximab-coated target cells is inhibited by the C3b component of complement

Antibody-dependent cellular cytotoxicity (ADCC) and complement fixation both appear to play a role in mediating antitumor effects of monoclonal antibodies (mAbs), including rituximab. We evaluated the relationship between rituximab-induced complement fixation, natural killer (NK)–cell activation, an...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Wang, Siao-Yi, Racila, Emilian, Taylor, Ronald P., Weiner, George J.
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2008
Assuntos:
Immunobiology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2214766/
https://ncbi.nlm.nih.gov/pubmed/18024795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-02-074716
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares