NK-cell activation and antibody-dependent cellular cytotoxicity induced by rituximab-coated target cells is inhibited by the C3b component of complement

Antibody-dependent cellular cytotoxicity (ADCC) and complement fixation both appear to play a role in mediating antitumor effects of monoclonal antibodies (mAbs), including rituximab. We evaluated the relationship between rituximab-induced complement fixation, natural killer (NK)–cell activation, an...

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Bibliographische Detailangaben
Hauptverfasser: Wang, Siao-Yi, Racila, Emilian, Taylor, Ronald P., Weiner, George J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2008
Schlagworte:
Immunobiology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2214766/
https://ncbi.nlm.nih.gov/pubmed/18024795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-02-074716
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