GA101 induces NK-cell activation and antibody-dependent cellular cytotoxicity more effectively than rituximab when complement is present

Both complement and antibody-dependent cellular cytotoxicity (ADCC) contribute to the clinical efficacy of anti-CD20 monoclonal antibody (mAb) therapy. Paradoxically, the C3b component of complement can block interaction between mAb and natural killer (NK) cells. The present study compared the effec...

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Hlavní autoři: Kern, Delila J., James, Britnie R., Blackwell, Sue, Gassner, Christian, Klein, Christian, Weiner, George J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3957421/
https://ncbi.nlm.nih.gov/pubmed/23452151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/10428194.2013.781169
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