Anti-CD20 monoclonal antibody with enhanced affinity for CD16 activates NK cells at lower concentrations and more effectively than rituximab

Growing evidence indicates that the affinity of monoclonal antibodies (mAbs) for CD16 (FcγRIII) plays a central role in the ability of the mAb to mediate antitumor activity. We evaluated how CD16 polymorphisms, and mAb with modified affinity for target antigen and CD16, affect natural killer (NK) ce...

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Detalhes bibliográficos
Main Authors: Bowles, Julie A., Wang, Siao-Yi, Link, Brian K., Allan, Barrett, Beuerlein, Gregory, Campbell, Mary-Ann, Marquis, David, Ondek, Brian, Wooldridge, James E., Smith, Brian J., Breitmeyer, James B., Weiner, George J.
Formato: Artigo
Idioma:Inglês
Publicado em: © 2006 by The American Society of Hematology 2006
Assuntos:
Immunobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895597/
https://ncbi.nlm.nih.gov/pubmed/16825493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-04-020057
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