Fc-dependent expression of CD137 on human NK cells: insights into “agonistic” effects of anti-CD137 monoclonal antibodies

CD137 (4-1BB) is a costimulatory mol-ecule that can be manipulated for the treatment of cancer and autoimmune disease. Although it is known that agonistic antibodies (mAbs) against CD137 enhance the rejection of murine tumors in a natural killer (NK) cell– and T cell–dependent fashion, the mechanism...

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Detalhes bibliográficos
Main Authors: Lin, Wei, Voskens, Caroline J., Zhang, Xiaoyu, Schindler, Daniel G., Wood, Aaron, Burch, Erin, Wei, Yadong, Chen, Lieping, Tian, Guoliang, Tamada, Koji, Wang, Lai-Xi, Schulze, Dan H., Mann, Dean, Strome, Scott E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2008
Assuntos:
Immunobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2481534/
https://ncbi.nlm.nih.gov/pubmed/18519814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-11-122465
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