Rapamycin improves lymphoproliferative disease in murine autoimmune lymphoproliferative syndrome (ALPS)

Autoimmune lymphoproliferative syndrome (ALPS) is a disorder of abnormal lymphocyte survival caused by defective Fas-mediated apoptosis, leading to lymphadenopathy, hepatosplenomegaly, and an increased number of double-negative T cells (DNTs). Treatment options for patients with ALPS are limited. Ra...

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Hauptverfasser: Teachey, David T., Obzut, Dana A., Axsom, Kelly, Choi, John K., Goldsmith, Kelly C., Hall, Junior, Hulitt, Jessica, Manno, Catherine S., Maris, John M., Rhodin, Nicholas, Sullivan, Kathleen E., Brown, Valerie I., Grupp, Stephan A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society of Hematology 2006
Schlagworte:
Immunobiology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895548/
https://ncbi.nlm.nih.gov/pubmed/16757690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-01-010124
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