Rapamycin improves lymphoproliferative disease in murine autoimmune lymphoproliferative syndrome (ALPS)

Autoimmune lymphoproliferative syndrome (ALPS) is a disorder of abnormal lymphocyte survival caused by defective Fas-mediated apoptosis, leading to lymphadenopathy, hepatosplenomegaly, and an increased number of double-negative T cells (DNTs). Treatment options for patients with ALPS are limited. Ra...

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Библиографические подробности
Главные авторы: Teachey, David T., Obzut, Dana A., Axsom, Kelly, Choi, John K., Goldsmith, Kelly C., Hall, Junior, Hulitt, Jessica, Manno, Catherine S., Maris, John M., Rhodin, Nicholas, Sullivan, Kathleen E., Brown, Valerie I., Grupp, Stephan A.
Формат: Artigo
Язык:Inglês
Опубликовано: The American Society of Hematology 2006
Предметы:
Immunobiology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895548/
https://ncbi.nlm.nih.gov/pubmed/16757690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-01-010124
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