Rapamycin improves lymphoproliferative disease in murine autoimmune lymphoproliferative syndrome (ALPS)

Autoimmune lymphoproliferative syndrome (ALPS) is a disorder of abnormal lymphocyte survival caused by defective Fas-mediated apoptosis, leading to lymphadenopathy, hepatosplenomegaly, and an increased number of double-negative T cells (DNTs). Treatment options for patients with ALPS are limited. Ra...

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書誌詳細
主要な著者: Teachey, David T., Obzut, Dana A., Axsom, Kelly, Choi, John K., Goldsmith, Kelly C., Hall, Junior, Hulitt, Jessica, Manno, Catherine S., Maris, John M., Rhodin, Nicholas, Sullivan, Kathleen E., Brown, Valerie I., Grupp, Stephan A.
フォーマット: Artigo
言語:Inglês
出版事項: The American Society of Hematology 2006
主題:
Immunobiology
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895548/
https://ncbi.nlm.nih.gov/pubmed/16757690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-01-010124
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