Rapamycin improves lymphoproliferative disease in murine autoimmune lymphoproliferative syndrome (ALPS)

Autoimmune lymphoproliferative syndrome (ALPS) is a disorder of abnormal lymphocyte survival caused by defective Fas-mediated apoptosis, leading to lymphadenopathy, hepatosplenomegaly, and an increased number of double-negative T cells (DNTs). Treatment options for patients with ALPS are limited. Ra...

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Détails bibliographiques
Auteurs principaux: Teachey, David T., Obzut, Dana A., Axsom, Kelly, Choi, John K., Goldsmith, Kelly C., Hall, Junior, Hulitt, Jessica, Manno, Catherine S., Maris, John M., Rhodin, Nicholas, Sullivan, Kathleen E., Brown, Valerie I., Grupp, Stephan A.
Format: Artigo
Langue:Inglês
Publié: The American Society of Hematology 2006
Sujets:
Immunobiology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895548/
https://ncbi.nlm.nih.gov/pubmed/16757690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-01-010124
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