Human complement receptor type 1–directed loading of tissue plasminogen activator on circulating erythrocytes for prophylactic fibrinolysis

Plasminogen activators (PAs) are not used for thromboprophylaxis due to rapid clearance, bleeding, and extravascular toxicity. We describe a novel strategy that overcomes these limitations. We conjugated tissue-type PA (tPA) to a monoclonal antibody (mAb) against complement receptor type 1 (CR1) exp...

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Bibliografiske detaljer
Main Authors: Zaitsev, Sergei, Danielyan, Kristina, Murciano, Juan-Carlos, Ganguly, Kumkum, Krasik, Tatiana, Taylor, Ronald P., Pincus, Steven, Jones, Steven, Cines, Douglas B., Muzykantov, Vladimir R.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society of Hematology 2006
Fag:
Hemostasis, Thrombosis, and Vascular Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895545/
https://ncbi.nlm.nih.gov/pubmed/16735601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-11-012336
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