Targeting of a Mutant Plasminogen Activator to Circulating Red Blood Cells for Prophylactic Fibrinolysis

Chemical coupling to carrier red blood cells (RBCs) converts tissue type plasminogen activator (tPA) from a problematic therapeutic into a safe agent for thromboprophylaxis. The goal of this study was to develop a more clinically relevant recombinant biotherapeutic by fusing a mutant tPA with a sing...

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Detalhes bibliográficos
Main Authors: Zaitsev, Sergei, Spitzer, Dirk, Murciano, Juan-Carlos, Ding, Bi-Sen, Tliba, Samira, Kowalska, M. Anna, Bdeir, Khalil, Kuo, Alice, Stepanova, Victoria, Atkinson, John P., Poncz, Mortimer, Cines, Douglas B., Muzykantov, Vladimir R.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2010
Assuntos:
Cardiovascular
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2835436/
https://ncbi.nlm.nih.gov/pubmed/19952305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.109.159194
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