Sustained thromboprophylaxis mediated by an RBC-targeted pro-urokinase zymogen activated at the site of clot formation

Plasminogen activators (PAs) are used to treat life-threatening thrombosis, but not for thromboprophylaxis because of rapid clearance, risk of bleeding, and central nervous system (CNS) toxicity. We describe a novel strategy that may help to overcome these limitations by targeting a thrombin-activat...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Zaitsev, Sergei, Spitzer, Dirk, Murciano, Juan-Carlos, Ding, Bi-Sen, Tliba, Samira, Kowalska, M. Anna, Marcos-Contreras, Oscar A., Kuo, Alice, Stepanova, Victoria, Atkinson, John P., Poncz, Mortimer, Cines, Douglas B., Muzykantov, Vladimir R.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society of Hematology 2010
Pynciau:
Thrombosis and Hemostasis
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2892950/
https://ncbi.nlm.nih.gov/pubmed/20410503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-01-261610
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg