Targeting recombinant thrombomodulin fusion protein to red blood cells provides multifaceted thromboprophylaxis

Thrombin generates fibrin and activates platelets and endothelium, causing thrombosis and inflammation. Endothelial thrombomodulin (TM) changes thrombin's substrate specificity toward cleavage of plasma protein C into activated protein C (APC), which opposes its thrombotic and inflammatory acti...

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Detalhes bibliográficos
Main Authors: Zaitsev, Sergei, Kowalska, M. Anna, Neyman, Michael, Carnemolla, Ronald, Tliba, Samira, Ding, Bi-Sen, Stonestrom, Aaron, Spitzer, Dirk, Atkinson, John P., Poncz, Mortimer, Cines, Douglas B., Esmon, Charles T., Muzykantov, Vladimir R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2012
Assuntos:
Thrombosis and Hemostasis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3367878/
https://ncbi.nlm.nih.gov/pubmed/22493296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-12-398149
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