Targeting recombinant thrombomodulin fusion protein to red blood cells provides multifaceted thromboprophylaxis

Thrombin generates fibrin and activates platelets and endothelium, causing thrombosis and inflammation. Endothelial thrombomodulin (TM) changes thrombin's substrate specificity toward cleavage of plasma protein C into activated protein C (APC), which opposes its thrombotic and inflammatory acti...

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Détails bibliographiques
Auteurs principaux: Zaitsev, Sergei, Kowalska, M. Anna, Neyman, Michael, Carnemolla, Ronald, Tliba, Samira, Ding, Bi-Sen, Stonestrom, Aaron, Spitzer, Dirk, Atkinson, John P., Poncz, Mortimer, Cines, Douglas B., Esmon, Charles T., Muzykantov, Vladimir R.
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2012
Sujets:
Thrombosis and Hemostasis
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3367878/
https://ncbi.nlm.nih.gov/pubmed/22493296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-12-398149
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