Targeting recombinant thrombomodulin fusion protein to red blood cells provides multifaceted thromboprophylaxis

Thrombin generates fibrin and activates platelets and endothelium, causing thrombosis and inflammation. Endothelial thrombomodulin (TM) changes thrombin's substrate specificity toward cleavage of plasma protein C into activated protein C (APC), which opposes its thrombotic and inflammatory acti...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Zaitsev, Sergei, Kowalska, M. Anna, Neyman, Michael, Carnemolla, Ronald, Tliba, Samira, Ding, Bi-Sen, Stonestrom, Aaron, Spitzer, Dirk, Atkinson, John P., Poncz, Mortimer, Cines, Douglas B., Esmon, Charles T., Muzykantov, Vladimir R.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society of Hematology 2012
Aiheet:
Thrombosis and Hemostasis
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3367878/
https://ncbi.nlm.nih.gov/pubmed/22493296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-12-398149
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