Platelet Endothelial Cell Adhesion Molecule Targeted Oxidant-Resistant Mutant Thrombomodulin Fusion Protein with Enhanced Potency In Vitro and In Vivo

Thrombomodulin (TM) is a glycoprotein normally present in the membrane of endothelial cells that binds thrombin and changes its substrate specificity to produce activated protein C (APC) that has antithrombotic and anti-inflammatory features. To compensate for loss of endogenous TM in pathology, we...

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Bibliographic Details
Main Authors: Carnemolla, Ronald, Greineder, Colin F., Chacko, Ann-Marie, Patel, Kruti Rajan, Ding, Bi-Sen, Zaitsev, Sergei, Esmon, Charles T., Muzykantov, Vladimir R.
Format: Artigo
Language:Inglês
Published: The American Society for Pharmacology and Experimental Therapeutics 2013
Subjects:
Drug Discovery and Translational Medicine
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3807068/
https://ncbi.nlm.nih.gov/pubmed/23965383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.113.205104
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