Vascular Immunotargeting to Endothelial Determinant ICAM-1 Enables Optimal Partnering of Recombinant scFv-Thrombomodulin Fusion with Endogenous Cofactor

The use of targeted therapeutics to replenish pathologically deficient proteins on the luminal endothelial membrane has the potential to revolutionize emergency and cardiovascular medicine. Untargeted recombinant proteins, like activated protein C (APC) and thrombomodulin (TM), have demonstrated ben...

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Detalhes bibliográficos
Main Authors: Greineder, Colin F., Chacko, Ann-Marie, Zaytsev, Sergei, Zern, Blaine J., Carnemolla, Ronald, Hood, Elizabeth D., Han, Jingyan, Ding, Bi-Sen, Esmon, Charles T., Muzykantov, Vladimir R.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3828233/
https://ncbi.nlm.nih.gov/pubmed/24244621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0080110
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