Vascular Immunotargeting to Endothelial Determinant ICAM-1 Enables Optimal Partnering of Recombinant scFv-Thrombomodulin Fusion with Endogenous Cofactor

The use of targeted therapeutics to replenish pathologically deficient proteins on the luminal endothelial membrane has the potential to revolutionize emergency and cardiovascular medicine. Untargeted recombinant proteins, like activated protein C (APC) and thrombomodulin (TM), have demonstrated ben...

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書誌詳細
主要な著者: Greineder, Colin F., Chacko, Ann-Marie, Zaytsev, Sergei, Zern, Blaine J., Carnemolla, Ronald, Hood, Elizabeth D., Han, Jingyan, Ding, Bi-Sen, Esmon, Charles T., Muzykantov, Vladimir R.
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2013
主題:
Research Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3828233/
https://ncbi.nlm.nih.gov/pubmed/24244621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0080110
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