Human complement receptor type 1–directed loading of tissue plasminogen activator on circulating erythrocytes for prophylactic fibrinolysis

Plasminogen activators (PAs) are not used for thromboprophylaxis due to rapid clearance, bleeding, and extravascular toxicity. We describe a novel strategy that overcomes these limitations. We conjugated tissue-type PA (tPA) to a monoclonal antibody (mAb) against complement receptor type 1 (CR1) exp...

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Bibliografske podrobnosti
Main Authors: Zaitsev, Sergei, Danielyan, Kristina, Murciano, Juan-Carlos, Ganguly, Kumkum, Krasik, Tatiana, Taylor, Ronald P., Pincus, Steven, Jones, Steven, Cines, Douglas B., Muzykantov, Vladimir R.
Format: Artigo
Jezik:Inglês
Izdano: The American Society of Hematology 2006
Teme:
Hemostasis, Thrombosis, and Vascular Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895545/
https://ncbi.nlm.nih.gov/pubmed/16735601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-11-012336
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