Human complement receptor type 1–directed loading of tissue plasminogen activator on circulating erythrocytes for prophylactic fibrinolysis

Plasminogen activators (PAs) are not used for thromboprophylaxis due to rapid clearance, bleeding, and extravascular toxicity. We describe a novel strategy that overcomes these limitations. We conjugated tissue-type PA (tPA) to a monoclonal antibody (mAb) against complement receptor type 1 (CR1) exp...

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Main Authors: Zaitsev, Sergei, Danielyan, Kristina, Murciano, Juan-Carlos, Ganguly, Kumkum, Krasik, Tatiana, Taylor, Ronald P., Pincus, Steven, Jones, Steven, Cines, Douglas B., Muzykantov, Vladimir R.
格式: Artigo
語言:Inglês
出版: The American Society of Hematology 2006
主題:
Hemostasis, Thrombosis, and Vascular Biology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895545/
https://ncbi.nlm.nih.gov/pubmed/16735601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-11-012336
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