Human complement receptor type 1–directed loading of tissue plasminogen activator on circulating erythrocytes for prophylactic fibrinolysis

Plasminogen activators (PAs) are not used for thromboprophylaxis due to rapid clearance, bleeding, and extravascular toxicity. We describe a novel strategy that overcomes these limitations. We conjugated tissue-type PA (tPA) to a monoclonal antibody (mAb) against complement receptor type 1 (CR1) exp...

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Detalhes bibliográficos
Main Authors: Zaitsev, Sergei, Danielyan, Kristina, Murciano, Juan-Carlos, Ganguly, Kumkum, Krasik, Tatiana, Taylor, Ronald P., Pincus, Steven, Jones, Steven, Cines, Douglas B., Muzykantov, Vladimir R.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society of Hematology 2006
Assuntos:
Hemostasis, Thrombosis, and Vascular Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895545/
https://ncbi.nlm.nih.gov/pubmed/16735601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-11-012336
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