Plasma inhibitory activity (PIA): a pharmacodynamic assay reveals insights into the basis for cytotoxic response to FLT3 inhibitors

We have developed a useful surrogate assay for monitoring the efficacy of FLT3 inhibition in patients treated with oral FLT3 inhibitors. The plasma inhibitory activity (PIA) for FLT3 correlates with clinical activity in patients treated with CEP-701 and PKC412. Using the PIA assay, along with in vit...

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Main Authors: Levis, Mark, Brown, Patrick, Smith, B. Douglas, Stine, Adam, Pham, Rosalyn, Stone, Richard, DeAngelo, Daniel, Galinsky, Ilene, Giles, Frank, Estey, Elihu, Kantarjian, Hagop, Cohen, Pamela, Wang, Yanfeng, Roesel, Johannes, Karp, Judith E., Small, Donald
Formáid: Artigo
Teanga:Inglês
Foilsithe: © 2006 by The American Society of Hematology 2006
Ábhair:
Neoplasia
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895426/
https://ncbi.nlm.nih.gov/pubmed/16857987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-04-015743
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