Internal tandem duplications of the FLT3 gene are present in leukemia stem cells

Internal tandem duplication mutations of the FLT3 gene (FLT3/ITD mutations) are the most frequent molecular abnormality in acute myeloid leukemia (AML) and are associated with a poor overall survival. While the normal FLT3 receptor is expressed in early hematopoietic progenitor cells, it has not bee...

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Autori principali: Levis, Mark, Murphy, Kathleen M., Pham, Rosalyn, Kim, Kyu-Tae, Stine, Adam, Li, Li, McNiece, Ian, Smith, B. Douglas, Small, Donald
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society of Hematology 2005
Soggetti:
Neoplasia
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895185/
https://ncbi.nlm.nih.gov/pubmed/15797998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2004-05-1902
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