A pharmacodynamic study of the FLT3 inhibitor KW-2449 yields insight into the basis for clinical response

Internal tandem duplication mutations of FLT3 (FLT3/ITD mutations) are common in acute myeloid leukemia (AML) and confer a poor prognosis. This would suggest that FLT3 is an ideal therapeutic target, but FLT3 targeted therapy has produced only modest benefits in clinical trials. Due to technical obs...

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Detalhes bibliográficos
Main Authors: Pratz, Keith W., Cortes, Jorge, Roboz, Gail J., Rao, Niranjan, Arowojolu, Omotayo, Stine, Adam, Shiotsu, Yukimasa, Shudo, Aiko, Akinaga, Shiro, Small, Donald, Karp, Judith E., Levis, Mark
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2009
Assuntos:
Clinical Trials and Observations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2673122/
https://ncbi.nlm.nih.gov/pubmed/19029442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-09-177030
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