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Bench to Bedside Targeting of FLT3 in Acute Leukemia

FMS-Like-Tyrosine kinase-3 (FLT3) mutations are found in about 30% of cases of acute myeloid leukemia and confer an increased relapse rate and reduced overall survival. Targeting this tyrosine kinase by direction inhibition is the focus of both preclinical and clinical research in AML. Several molec...

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Bibliografske podrobnosti
Main Authors: Pratz, Keith W., Levis, Mark J.
Format: Artigo
Jezik:Inglês
Izdano: 2010
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3023996/
https://ncbi.nlm.nih.gov/pubmed/20370649
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