FLT3 ligand impedes the efficacy of FLT3 inhibitors in vitro and in vivo

We examined in vivo FLT3 inhibition in acute myeloid leukemia patients treated with chemotherapy followed by the FLT3 inhibitor lestaurtinib, comparing newly diagnosed acute myeloid leukemia patients with relapsed patients. Because we noted that in vivo FLT3 inhibition by lestaurtinib was less effec...

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Bibliographische Detailangaben
Hauptverfasser: Sato, Takashi, Yang, Xiaochuan, Knapper, Steven, White, Paul, Smith, B. Douglas, Galkin, Steven, Small, Donald, Burnett, Alan, Levis, Mark
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2011
Schlagworte:
Clinical Trials and Observations
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069670/
https://ncbi.nlm.nih.gov/pubmed/21263155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-01-266742
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