Negative regulation of CXCR4-mediated chemotaxis by the lipid phosphatase activity of tumor suppressor PTEN

Phosphatase and tensin homolog deleted on chromosome 10 (PTEN), a multifunctional tumor suppressor, has been shown to play a regulatory role in cell migration. Dictyostelium discoideum cells lacking PTEN exhibited impaired migration toward chemoattractant gradients. In the present study, we investig...

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Bibliographic Details
Main Authors: Gao, Ping, Wange, Ronald L., Zhang, Ning, Oppenheim, Joost J., Howard, O. M. Zack
Format: Artigo
Language:Inglês
Published: The American Society of Hematology 2005
Subjects:
Chemokines, Cytokines, and Interleukins
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895312/
https://ncbi.nlm.nih.gov/pubmed/15994292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2004-08-3362
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