BH3-only proteins Puma and Bim are rate-limiting for γ-radiation– and glucocorticoid-induced apoptosis of lymphoid cells in vivo

Numerous p53 target genes have been implicated in DNA damage–induced apoptosis signaling, but proapoptotic Bcl-2 (B-cell leukemia 2) family members of the BH3 (Bcl-2 homolog region [BH] 3)–only subgroup appear to play the critical initiating role. In various types of cultured cells, 3 BH3-only prote...

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Hlavní autoři: Erlacher, Miriam, Michalak, Ewa M., Kelly, Priscilla N., Labi, Verena, Niederegger, Harald, Coultas, Leigh, Adams, Jerry M., Strasser, Andreas, Villunger, Andreas
Médium: Artigo
Jazyk:Inglês
Vydáno: © 2005 by The American Society of Hematology 2005
Témata:
Hematopoiesis
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895232/
https://ncbi.nlm.nih.gov/pubmed/16118324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-04-1595
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