Antigen-specific T-cell memory is preserved in children treated for acute lymphoblastic leukemia

Despite profound T-cell immunodeficiency, most patients treated with chemotherapy do not succumb to infection. The basis for residual protective immunity in lymphopenic patients is not known. We prospectively measured T-cell numbers, thymopoiesis, and T-cell memory in 73 children undergoing a 2-year...

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Autori principali: Haining, W. Nicholas, Neuberg, Donna S., Keczkemethy, Heather L., Evans, John W., Rivoli, Stephen, Gelman, Rebecca, Rosenblatt, Howard M., Shearer, William T., Guenaga, Javier, Douek, Daniel C., Silverman, Lewis B., Sallan, Stephen E., Guinan, Eva C., Nadler, Lee M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society of Hematology 2005
Soggetti:
Immunobiology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895221/
https://ncbi.nlm.nih.gov/pubmed/15920008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-03-1082
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