Antigen-specific T-cell memory is preserved in children treated for acute lymphoblastic leukemia

Despite profound T-cell immunodeficiency, most patients treated with chemotherapy do not succumb to infection. The basis for residual protective immunity in lymphopenic patients is not known. We prospectively measured T-cell numbers, thymopoiesis, and T-cell memory in 73 children undergoing a 2-year...

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Autores principales: Haining, W. Nicholas, Neuberg, Donna S., Keczkemethy, Heather L., Evans, John W., Rivoli, Stephen, Gelman, Rebecca, Rosenblatt, Howard M., Shearer, William T., Guenaga, Javier, Douek, Daniel C., Silverman, Lewis B., Sallan, Stephen E., Guinan, Eva C., Nadler, Lee M.
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society of Hematology 2005
Materias:
Immunobiology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895221/
https://ncbi.nlm.nih.gov/pubmed/15920008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-03-1082
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