PF4/heparin complexes are T cell–dependent antigens

Heparin-induced thrombocytopenia (HIT) is a life-threatening, thrombotic disorder associated with development of anti–platelet factor 4 (anti-PF4)/heparin autoantibodies. Little is known about the antigenic and cellular requirements that initiate the immune response to these complexes. To begin to d...

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Detalhes bibliográficos
Main Authors: Suvarna, Shayela, Rauova, Lubica, McCracken, Emily K. E., Goss, Christina M., Sachais, Bruce S., McKenzie, Steven E., Reilly, Michael P., Gunn, Michael Dee, Cines, Douglas B., Poncz, Mortimer, Arepally, Gowthami
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society of Hematology 2005
Assuntos:
Hemostasis, Thrombosis, and Vascular Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895158/
https://ncbi.nlm.nih.gov/pubmed/15845897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2004-12-4955
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