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Src family kinase–mediated and Erk-mediated thromboxane A2 generation are essential for VWF/GPIb-induced fibrinogen receptor activation in human platelets

The binding of von Willebrand factor (VWF) to the platelet membrane glycoprotein Ib-IX (GPIb-IX) results in platelet activation. In this study, we sought to clarify previous conflicting reports and to elucidate the mechanism of activation and the precise role of extracellular signal-regulated kinase...

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Bibliografske podrobnosti
Main Authors: Garcia, Analia, Quinton, Todd M., Dorsam, Robert T., Kunapuli, Satya P.
Format: Artigo
Jezik:Inglês
Izdano: The American Society of Hematology 2005
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895051/
https://ncbi.nlm.nih.gov/pubmed/16020504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-05-1933
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