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The Mechanism of VWF-Mediated Platelet GPIbα Binding
The binding of Von Willebrand Factor to platelets is dependent on the conformation of the A1 domain which binds to platelet GPIbα. This interaction initiates the adherence of platelets to the subendothelial vasculature under the high shear that occurs in pathological thrombosis. We have developed a...
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| Autores principales: | , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
The Biophysical Society
2010
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2920722/ https://ncbi.nlm.nih.gov/pubmed/20713003 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2010.06.002 |
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