Changes in Thermodynamic Stability of von Willebrand Factor Differentially Affect the Force-Dependent Binding to Platelet GPIbα

In circulation, plasma glycoprotein von Willebrand Factor plays an important role in hemostasis and in pathological thrombosis under hydrodynamic forces. Mutations in the A1 domain of von Willebrand factor cause the hereditary types 2B and 2M von Willebrand disease that either enhance (2B) or inhibi...

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Detalhes bibliográficos
Main Authors: Auton, Matthew, Sedlák, Erik, Marek, Jozef, Wu, Tao, Zhu, Cheng, Cruz, Miguel A.
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2009
Assuntos:
Protein
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2711320/
https://ncbi.nlm.nih.gov/pubmed/19619477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2009.05.009
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