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Kinetics of GPIbα-vWF-A1 Tether Bond under Flow: Effect of GPIbα Mutations on the Association and Dissociation Rates

The interaction between platelet glycoprotein (GP) Ib-IX-V complex and von Willebrand factor (vWF) is the first step of the hemostatic response to vessel injury. In platelet-type von Willebrand disease, two mutations, G233V and M239V, have been described within the Cys(209)-Cys(248) disulfide loop o...

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Bibliografski detalji
Glavni autori: Kumar, R. Anand, Dong, Jing-fei, Thaggard, Jenny A., Cruz, Miguel A., López, José A., McIntire, Larry V.
Format: Artigo
Jezik:Inglês
Izdano: Biophysical Society 2003
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1303709/
https://ncbi.nlm.nih.gov/pubmed/14645097
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