GPIbα-vWF Rolling under Shear Stress Shows Differences between Type 2B and 2M von Willebrand Disease

Both type 2B and type 2M von Willebrand disease result in bleeding disorders; however, whereas type 2B has increased binding affinity between platelet glycoprotein Ibα and von Willebrand factor (vWF), type 2M has decreased binding affinity between these two molecules. We used R687E type 2B and G561S...

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Bibliographische Detailangaben
Hauptverfasser: Coburn, L.A., Damaraju, V.S., Dozic, S., Eskin, S.G., Cruz, M.A., McIntire, L.V.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Biophysical Society 2011
Schlagworte:
Biological Systems and Multicellular Dynamics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3021665/
https://ncbi.nlm.nih.gov/pubmed/21244826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2010.11.084
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