Platelet glycoprotein Ibα forms catch bonds with human WT vWF but not with type 2B von Willebrand disease vWF

Arterial blood flow enhances glycoprotein Ibα (GPIbα) binding to vWF, which initiates platelet adhesion to injured vessels. Mutations in the vWF A1 domain that cause type 2B von Willebrand disease (vWD) reduce the flow requirement for adhesion. Here we show that increasing force on GPIbα/vWF bonds f...

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Detalhes bibliográficos
Main Authors: Yago, Tadayuki, Lou, Jizhong, Wu, Tao, Yang, Jun, Miner, Jonathan J., Coburn, Leslie, López, José A., Cruz, Miguel A., Dong, Jing-Fei, McIntire, Larry V., McEver, Rodger P., Zhu, Cheng
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2518822/
https://ncbi.nlm.nih.gov/pubmed/18725999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI35754
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