Platelet glycoprotein Ibα forms catch bonds with human WT vWF but not with type 2B von Willebrand disease vWF

Arterial blood flow enhances glycoprotein Ibα (GPIbα) binding to vWF, which initiates platelet adhesion to injured vessels. Mutations in the vWF A1 domain that cause type 2B von Willebrand disease (vWD) reduce the flow requirement for adhesion. Here we show that increasing force on GPIbα/vWF bonds f...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Yago, Tadayuki, Lou, Jizhong, Wu, Tao, Yang, Jun, Miner, Jonathan J., Coburn, Leslie, López, José A., Cruz, Miguel A., Dong, Jing-Fei, McIntire, Larry V., McEver, Rodger P., Zhu, Cheng
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2008
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2518822/
https://ncbi.nlm.nih.gov/pubmed/18725999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI35754
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky