Platelet glycoprotein Ibα forms catch bonds with human WT vWF but not with type 2B von Willebrand disease vWF

Arterial blood flow enhances glycoprotein Ibα (GPIbα) binding to vWF, which initiates platelet adhesion to injured vessels. Mutations in the vWF A1 domain that cause type 2B von Willebrand disease (vWD) reduce the flow requirement for adhesion. Here we show that increasing force on GPIbα/vWF bonds f...

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Bibliografiske detaljer
Main Authors: Yago, Tadayuki, Lou, Jizhong, Wu, Tao, Yang, Jun, Miner, Jonathan J., Coburn, Leslie, López, José A., Cruz, Miguel A., Dong, Jing-Fei, McIntire, Larry V., McEver, Rodger P., Zhu, Cheng
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2008
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2518822/
https://ncbi.nlm.nih.gov/pubmed/18725999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI35754
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