The β3 subunit of the integrin αIIbβ3 regulates αIIb-mediated outside-in signaling

Bidirectional signaling is an essential feature of αIIbβ3 function. The αIIb cytoplasmic domain negatively regulates β3-mediated inside-out signaling, but little is known about the regulation of αIIb-mediated outside-in signaling. We show that αIIb-mediated outside-in signaling is enhanced in platel...

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Bibliografiske detaljer
Main Authors: Liu, Junling, Jackson, Carl W., Gruppo, Ralph A., Jennings, Lisa K., Gartner, T. Kent
Format: Artigo
Sprog:Inglês
Udgivet: © 2005 by The American Society of Hematology 2005
Fag:
Hemostasis, Thrombosis, and Vascular Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895035/
https://ncbi.nlm.nih.gov/pubmed/15701721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2004-07-2718
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