Aberrant subcellular targeting of the G185R neutrophil elastase mutant associated with severe congenital neutropenia induces premature apoptosis of differentiating promyelocytes

Mutations in the ELA2 gene encoding neutrophil elastase (NE) are present in most patients with severe congenital neutropenia (SCN). However, the mechanisms by which these mutations cause neutropenia remain unknown. To investigate the effects of mutant NE expression on granulopoiesis, we used the HL-...

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Detaylı Bibliyografya
Asıl Yazarlar: Massullo, Pam, Druhan, Lawrence J., Bunnell, Bruce A., Hunter, Melissa G., Robinson, John M., Marsh, Clay B., Avalos, Belinda R.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: © 2005 by The American Society of Hematology 2005
Konular:
Plenary Papers
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895019/
https://ncbi.nlm.nih.gov/pubmed/15657182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2004-07-2618
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