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Neutrophil Elastase Defects in Congenital Neutropenia

Severe congenital neutropenia (SCN) is a rare hematological condition with heterogenous genetic background. Neutrophil elastase (NE) encoded by ELANE gene is mutated in over half of the SCN cases. The role of NE defects in myelocytes maturation arrest in bone marrow is widely investigated; however,...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Rydzynska, Zuzanna, Pawlik, Bartlomiej, Krzyzanowski, Damian, Mlynarski, Wojciech, Madzio, Joanna
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8100030/
https://ncbi.nlm.nih.gov/pubmed/33968054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.653932
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