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Elastase inhibitors as potential therapies for ELANE-associated neutropenia

Mutations in ELANE, the gene for neutrophil elastase (NE), a protease expressed early in neutrophil development, are the most frequent cause of cyclic (CyN) and severe congenital neutropenia (SCN). We hypothesized that inhibitors of NE, acting either by directly inhibiting enzymatic activity or as c...

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Dettagli Bibliografici
Pubblicato in:J Leukoc Biol
Autori principali: Makaryan, Vahagn, Kelley, Merideth L., Fletcher, Breanna, Bolyard, Audrey Anna, Aprikyan, A. Andrew, Dale, David C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Leukocyte Biology 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5597518/
https://ncbi.nlm.nih.gov/pubmed/28754797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.5A1016-445R
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