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Elastase inhibitors as potential therapies for ELANE-associated neutropenia
Mutations in ELANE, the gene for neutrophil elastase (NE), a protease expressed early in neutrophil development, are the most frequent cause of cyclic (CyN) and severe congenital neutropenia (SCN). We hypothesized that inhibitors of NE, acting either by directly inhibiting enzymatic activity or as c...
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| Pubblicato in: | J Leukoc Biol |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Society for Leukocyte Biology
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5597518/ https://ncbi.nlm.nih.gov/pubmed/28754797 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.5A1016-445R |
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