Elastase inhibitors as potential therapies for ELANE-associated neutropenia

Mutations in ELANE, the gene for neutrophil elastase (NE), a protease expressed early in neutrophil development, are the most frequent cause of cyclic (CyN) and severe congenital neutropenia (SCN). We hypothesized that inhibitors of NE, acting either by directly inhibiting enzymatic activity or as c...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Leukoc Biol
Auteurs principaux: Makaryan, Vahagn, Kelley, Merideth L., Fletcher, Breanna, Bolyard, Audrey Anna, Aprikyan, A. Andrew, Dale, David C.
Format: Artigo
Langue:Inglês
Publié: Society for Leukocyte Biology 2017
Sujets:
Translational & Clinical Immunology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5597518/
https://ncbi.nlm.nih.gov/pubmed/28754797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.5A1016-445R
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