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Elastase inhibitors as potential therapies for ELANE-associated neutropenia

Mutations in ELANE, the gene for neutrophil elastase (NE), a protease expressed early in neutrophil development, are the most frequent cause of cyclic (CyN) and severe congenital neutropenia (SCN). We hypothesized that inhibitors of NE, acting either by directly inhibiting enzymatic activity or as c...

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Detalhes bibliográficos
Publicado no:J Leukoc Biol
Main Authors: Makaryan, Vahagn, Kelley, Merideth L., Fletcher, Breanna, Bolyard, Audrey Anna, Aprikyan, A. Andrew, Dale, David C.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Leukocyte Biology 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5597518/
https://ncbi.nlm.nih.gov/pubmed/28754797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.5A1016-445R
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