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Elastase inhibitors as potential therapies for ELANE-associated neutropenia
Mutations in ELANE, the gene for neutrophil elastase (NE), a protease expressed early in neutrophil development, are the most frequent cause of cyclic (CyN) and severe congenital neutropenia (SCN). We hypothesized that inhibitors of NE, acting either by directly inhibiting enzymatic activity or as c...
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| Izdano u: | J Leukoc Biol |
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| Glavni autori: | , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Society for Leukocyte Biology
2017
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5597518/ https://ncbi.nlm.nih.gov/pubmed/28754797 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.5A1016-445R |
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