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Neutrophil elastase in cyclic and severe congenital neutropenia

Mutations in ELA2 encoding the neutrophil granule protease, neutrophil elastase (NE), are the major cause of the 2 main forms of hereditary neutropenia, cyclic neutropenia and severe congenital neutropenia (SCN). Genetic evaluation of other forms of neutropenia in humans and model organisms has help...

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Autori principali: Horwitz, Marshall S., Duan, Zhijun, Korkmaz, Brice, Lee, Hu-Hui, Mealiffe, Matthew E., Salipante, Stephen J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2007
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1801070/
https://ncbi.nlm.nih.gov/pubmed/17053055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-08-019166
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