Neutrophil elastase downmodulates native G-CSFR expression and granulocyte-macrophage colony formation

BACKGROUND: The granulocyte colony-stimulating factor receptor (G-CSFR) plays a critical role in maintaining homeostatic levels of circulating neutrophils (PMN). The mechanisms modulating G-CSFR surface expression to prevent chronic neutrophilia are poorly understood. Here, we report that neutrophil...

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Hlavní autoři: Piper, Melissa G, Massullo, Pam R, Loveland, Megan, Druhan, Lawrence J, Kindwall-Keller, Tamila L, Ai, Jing, Copelan, Alexander, Avalos, Belinda R
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2010
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2824667/
https://ncbi.nlm.nih.gov/pubmed/20205821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-9255-7-5
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