Aberrant subcellular targeting of the G185R neutrophil elastase mutant associated with severe congenital neutropenia induces premature apoptosis of differentiating promyelocytes

Mutations in the ELA2 gene encoding neutrophil elastase (NE) are present in most patients with severe congenital neutropenia (SCN). However, the mechanisms by which these mutations cause neutropenia remain unknown. To investigate the effects of mutant NE expression on granulopoiesis, we used the HL-...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Massullo, Pam, Druhan, Lawrence J., Bunnell, Bruce A., Hunter, Melissa G., Robinson, John M., Marsh, Clay B., Avalos, Belinda R.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: © 2005 by The American Society of Hematology 2005
Aiheet:
Plenary Papers
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895019/
https://ncbi.nlm.nih.gov/pubmed/15657182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2004-07-2618
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