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Lnk inhibits erythropoiesis and Epo-dependent JAK2 activation and downstream signaling pathways
Erythropoietin (Epo), along with its receptor EpoR, is the principal regulator of red cell development. Upon Epo addition, the EpoR signaling through the Janus kinase 2 (JAK2) activates multiple pathways including Stat5, phosphoinositide-3 kinase (PI-3K)/Akt, and p42/44 mitogen-activated protein kin...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The American Society of Hematology
2005
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1894992/ https://ncbi.nlm.nih.gov/pubmed/15705783 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2004-10-4093 |
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