The HIF Signaling Pathway in Osteoblasts Directly Modulates Erythropoiesis Through the Production of EPO

Osteoblasts are an important component of the hematopoietic microenvironment in bone. However, the mechanisms by which osteoblasts control hematopoiesis remain unknown. We show that augmented HIF signaling in osteoprogenitors results in HSC niche expansion associated with selective expansion of the...

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Autori principali: Rankin, Erinn B., Wu, Colleen, Khatri, Richa, Wilson, Tremika LS, Andersen, Rebecca, Araldi, Elisa, Rankin, Andrew L., Yuan, Jenny, Kuo, Calvin J., Schipani, Ernestina, Giaccia, Amato J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3408231/
https://ncbi.nlm.nih.gov/pubmed/22464323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.01.051
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