The HIF Signaling Pathway in Osteoblasts Directly Modulates Erythropoiesis Through the Production of EPO

Osteoblasts are an important component of the hematopoietic microenvironment in bone. However, the mechanisms by which osteoblasts control hematopoiesis remain unknown. We show that augmented HIF signaling in osteoprogenitors results in HSC niche expansion associated with selective expansion of the...

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Main Authors: Rankin, Erinn B., Wu, Colleen, Khatri, Richa, Wilson, Tremika LS, Andersen, Rebecca, Araldi, Elisa, Rankin, Andrew L., Yuan, Jenny, Kuo, Calvin J., Schipani, Ernestina, Giaccia, Amato J.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3408231/
https://ncbi.nlm.nih.gov/pubmed/22464323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.01.051
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