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A tightly-packed hydrophobic cluster directs the formation of an off-pathway sub-millisecond folding intermediate in the alpha subunit of tryptophan synthase, a TIM barrel protein
Protein misfolding is now recognized as playing a crucial role in both normal and pathogenic folding reactions. An interesting example of misfolding at the earliest state of a natural folding reaction is provided by the alpha subunit of tryptophan synthase, a (β/α)(8) TIM barrel protein. The molecul...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2006
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1894912/ https://ncbi.nlm.nih.gov/pubmed/17222865 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2006.12.005 |
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